Time, complexity, entropy, and the multiverse

FQXi, the Foundational Questions Institute, held a multidisciplinary meeting investigating the Nature of Time in Scandinavia August 27 – September 1, 2011 (Figure 1). FQXi promulgates original thinking and research on fundamental questions in physics and cosmology through research grants and essay-writing contests on topics such as “The Nature of Time,” and “Is Reality Digital or Analog?”

Figure 1. Multidisciplinary topics covered at the FQXi Time Conference

Time is familiar in the sense of the three space dimensions and the one time dimension around which human affairs in the physical world are organized. Additionally, each person has a subjective and identifiable relationship to time, even though this may be little more than a convenient construct. In science, time has been developed to the greatest degree in physics and cosmology, and in the philosophy of science. Other fields too are starting to consider time more robustly, including complexity, biology, and computation.

The conference addressed the issue of the arrow of time from many perspectives. While most fundamental laws of nature are time-symmetric, some areas have a time arrow flowing in one direction such as thermodynamics, quantum theory, radiation, and gravity. This can be problematic to explain. A suggested analysis structure involving the trade-offs between complexity and entropy as systems evolve over time served as a useful model for analyzing different aspects of time throughout the meeting.

Inciting Brownian motion at the macro-scale

Entropy is the process of moving from order to disorder, for example one’s desk becoming cluttered after being cleaned. In many cases, lower entropy states are desirable as they connote greater order. Without doing work to decrease entropy, it generally increases at the macro level (the spacetime of objects that humans encounter on a daily basis). Entropy increases and time appears to move only forward.

At the micro scale of atoms, Brownian motion occurs (the constant jiggling of atoms), and creates an important case where the Second Law of Thermodynamics (heat eventually dissipates; systems move from being warm to cold) does not hold. Brownian motion at the micro scale also allows fluctuations in the arrow of time and in entropy, e.g.; time may flow forwards and backwards, and there may be fluctuations towards lower and higher states of entropy. This can be seen not just at the very-very small Planck scale and the atomic scale of statistical mechanics (for example, atoms jiggling in a gas), but also at the level of cells in the body, and in another example, pollen cells suspended just the right way in water.

That Brownian motion can occur at the comparatively larger scale of cells suggests that it may occur, or be induced to occur at even more macro levels too. For example, in complex adaptive systems, an economy has phases of Brownian motion, when rational agents are jiggling constantly to make the invisible hand of supply and demand meet. Perhaps incentive structures including policy may be used to facilitate the persistence of Brownian motion and devolution of entropy in macro-level systems.

A system is a balance: complex systems design

The Inconsistency Robustness symposium held at Stanford August 16-18, 2011 featured discussion of a number of challenges that arise in the design of complex systems, and potential solutions to them. The dialogue ranged from computer science details (for example, message passing in concurrent systems) to systemic assessments (for example, ecological concerns and homeostasis). Researcher attendees applied their varied backgrounds to the discussion.

A universal point in complex systems design is the importance of expecting and incorporating inconsistency and potential points of failure into a system. Flexible robust systems may be dynamical and adaptive within boundaries (Figure 1 - "Complex Dynamical") provided there is some mechanism for identifying and monitoring potential out-of-bounds conditions.

Figure 1. Three patterns of behavior in complex dynamical systems (Source)

Scaling citizen health science and ethical review

Many things are needed to scale citizen science from small cohorts on the order of a few individuals to medium and large-sized cohorts. Building trust in online health communities, motivating sustained engagement from study participants, and lower-cost easier-access blood tests are a few things that are needed.

Legal and ethical issues are also a challenge. Independent ethical review is appropriate but the current IRB (Institutional Review Board) requirement for funding and journal publication is a barrier to crowdsourced study growth. In 23andMe's early studies, there was a definitional debate as to whether their research constituted 'human subjects research,' and whether there was a difference in interacting with subjects in-person versus over the internet.

The U.S. HHS (Health and Human Services) definition of 'humans subjects research' is research that "obtains (1) data through intervention or interaction with the individual, or (2) identifiable private information." (45 CFR 46.102(f)) The strict reading is that any research obtained by 'interacting' with a human subject (e.g.; likely all personalized health collaboration community research) would require an IRB for the funding needed to do it at scale.

Acknowledgement: Thank you to Thomas Pickard for providing background research

Further advance in the integration of organic and inorganic matter

A fundamental research focus in nanotechnology is the deliberate creation of organic-inorganic hybrids such as rotaxanes that have the properties of both organic and inorganic matter. These nanomaterials can greatly extend the range of control and manipulation that can occur in nanomedicine and other applications.

One interesting recent example is engineered fusion proteins, inorganic-binding peptides conjugated with bioluminescence proteins. The fusion proteins can be used as bioimaging molecular probes both targeting minerals (through fluorescence labeling) and monitoring the rate of biomineralization (through induced reactions). (Yuca et al., Biotechnol Bioeng. 2011 May;108(5):1021-30.)

Figure 1. Integrating organic and inorganic materials: graphene sheet sandwiched in the hydrophobic interior of a phospholipid

Another example (Figure 1) is graphene sheets sandwiched in the hydrophobic interior of a phospholipid. The phospholipid layers of the membrane electrically isolate the embedded graphene from the external solution which means that the composite system could be used in the development of biosensors and bioelectronic materials. (Titov et al., ACS Nano. 2010 Jan 26;4(1):229-34.)

Consciousness only exists as a human construct

It is quite possible that consciousness may not be an objectively definable phenomenon, but rather a convenient illusion created by humans to provide a context for understanding reality. While machines such as CT scans and MRIs measure human cognition, it may not be possible to measure the direct qualities of consciousness. Philosophers and others have pointed out that consciousness may be a subjective quality arising from the operation of the brain.

One reason that a more detailed look at consciousness may be interesting is in the contemplation of non-human intelligence. Given the aspect of subjective qualia surrounding the label consciousness, it might be insulting to non-human intelligence to be referred to as having consciousness, the more objective attribute ‘self-aware’ being preferable. If human consciousness does not exist, non-human consciousness would be even less likely to exist.

Longevity genomics paper retracted

On July 22, 2011, a high-profile longevity genomics paper published in Science in July 2010 was retracted. The paper, ‘Genetic Signatures of Exceptional Longevity in Humans,’ was the work of Thomas Perls and Paola Sebastiani (Boston University). The initial study had been revised per editorial concerns that arose last year, but has now been retracted possibly due to issues related to the replicatability the findings.

The revised study results were presented by the team at the American Aging Association meeting in June 2011. These data featured nine single SNP associations (versus two previously), and linked 281 SNPs to signatures for exceptional longevity (versus 180 SNPs previously). The overall conclusion remained unchanged - that

centenarians, while having the same disease mutational profiles as non-centenarians, have other specific aspects to their genetic profiles which indicate a signature for exceptional longevity

Towards an epistemology of citizen science

Now that citizen science in the health domain is becoming more established, it is relevant to scale it up to tackle larger projects. Several things can be done such as the definition and introduction of liability and oversight models that would be the analogue of the traditional IRB (institutional review board), and the professionalization of participant roles in the study ecosystem such as that of the study manager.

A more subtle issue is to develop an epistemology of citizen science. This would provide a structure and context for exploring the knowledge that is derived from citizen science. One question is whether new kinds of knowledge are being formed through group collaborations such as wikipedia and health social networks. Another question is characterizing the differences (if any) in the types of knowledge generated by traditional medicine, self-experimentation, and health collaboration communities.

Practical applications in anti-aging

One nice aspect of aging conferences is that there are usually a few gems of information that can be applied immediately in humans. Several actionable solutions were highlighted at the 40th annual meeting of the American Aging Association held June 3-6, 2011 in Raleigh NC USA (conference summary), in the areas of pharmaceuticals, nutrition, lifestyle, exercise, and fasting.

In summary, hypertension drug losartan may help sarcopenia, the healthier fats and antioxidants in walnuts, blueberries, and nectarines may facilitate health, hot tubs may reduce blood pressure, endurance exercise is better for older adults, and protein restriction may be the best form of caloric restriction.

In detail...

• In pharmaceuticals, the prescription drug losartan (an angiotensin receptor blocker) is typically used to treat hypertension and high blood pressure. It may also have anti-aging benefits in combating sarcopenia and frailty by improving muscle remodeling and grip strength.

• In nutrition, recommendations were for walnuts, blueberries, and nectarines. Walnuts are good because they are the only nut containing a significant amount of alpha-linolenic acid (ALA), and because they are mainly composed of polyunsaturated fatty acids (PUFA, both omega-3 and omega-6) rather than monounsaturated fatty acids (MUFA), as most other nuts. Blueberries continue to be an important suggestion for anti-aging. They contain anthocyanins, antioxidants which may prevent inflammation and help to improve brain signals and memory function. The 2011 Blueberry Health Study reported that individual cognitive performance improved 1% over a one year period from consuming one half cup to two cups of blueberries per day. Necatrines (and acai) also have antioxidant properties and have been found to reduce oxidative damage and improve longevity in Drosophila melanogaster (Boyd, Free Radic Biol Med, 2011).

• A lifestyle anti-aging remedy was found in nonhuman primates. Heated hydrotherapy, e.g.; jacuzzis, two times a week for 30 minutes at 39-41 degrees C, induced heat shock response (which declines with age) and increased production of heat shock proteins 70 and 90 which resulted in reduced blood pressure.

• Exercise is always a good anti-aging improvement especially since 60% of U.S. adults over 60 have insufficient physical activity. Type II fibers (fast-twitch) are most vulnerable to aging so instead of trying to improve these, for older adults, it is better and easier to maintain Type I fibers associated with endurance exercise. For example, 70-80 year olds running 2-3 miles a few times a week had the glucoregulation profiles of sedentary adults in their 20s.
  

• Fasting, especially amino acid (e.g.; protein) deprivation, before chemotherapy and surgery was found to help in reducing injurious impact.

World supercomputing capability more than triples

In a breath of good news for Japan this year, RIKEN's supercomputer "K Computer" vaulted to the top slot in world supercomputing in June 2011 as tracked by Top 500 Supercomputer Sites.

Remarkably, capability more than tripled to over 8 petaflops per second (8 quadrillion calculations per second, measured as the Maximal LINPACK performance achieved), after supercomputer performance had been asymptoting at close to 1 pf and 2 pfs for the last three years (Figure 1). China's Tianhe-1A at the National Supercomputing Center in Tianjin was in second place, and the US's Jaguar Cray at Oak Ridge National Lab in third.

The capacity tripling constitutes obvious potential benefits to scientific computing, the realm of applications for which supercomputers are used. It is hoped that these kinds of quantitative changes may eventually lead to qualitative changes in the way other problems are investigated, for example how the brain works.

Figure 1. Source: Top 500 Supercomputer Sites