iPhone Biodefense App

Right now it would be nice for people to be able to perform a detailed inspection of whatever environment they are in, and of themselves internally. As the future evolves, it could become an exigency. Portable personal biosensing devices for biothreat defense and medical self-diagnosis could become de rigueur, most logically as an extension of current mobile device platforms.

Hardware Requirements:

• Integrated Lab-on-a-chip module with flow cytometer, real-time PCR, microarray and sequencing unit (genome, proteome, metabolome, lipidome, etc.)
• Disposable finger-prick lancets

Software Requirements:

• Data is collected and perhaps digitized locally, then transmitted for processing and interpretation via web services

What is the current status of the iPhone Biodefense App?

• A. Order online
• B. DIY with components from Fry’s
• C. Have a roadmap, getting supplies and building tools
• D. Homesteads and landgrab available to pioneers
• E. “Ahead of the science,” aka it’s always 20 years out!

Answer: C. Have a roadmap, getting supplies and building tools
Single-cell identification, extraction and genotyping is starting to be possible from a research perspective (ex: Love Lab, MIT). Lab-on-a-chip functionality has been miniaturized (e.g.; small flow cytometers, small PCR machines). Now the trick is to integrate and add features to these systems, extend the functionality, shrink them further and reduce constraints. Microarrays and sequencing also have several innovation cycles ahead.

Key constraint: time
In addition to moving down the cost curve (most relevant for sequencing), performance time is the key constraint. Substances, expressed genes, blood biomarkers, etc. can be detected but it is taking hours and days when it needs to be immediate.

Declassify custom biodefense microarrays
Lawrence Livermore National Laboratory has one of the most advanced biodefense labs in the country. Custom microarrays have been developed for government agencies that the lab would now like to transfer into the public health domain. This could revolutionize and hasten commercial biosensing applications much like the declassification of adaptive optics revolutionized astronomy. At least three custom microarrays have been developed:

• Microbial Detection Array: identify what a substance is
• Virulence Array: identify how much damage a substance could do
• Microbial Defense Genotyping Array: identify SNPs, indels

Top 10 Computing Trends for 2009

Here is a quick list of my top computing and communications predictions for 2009 ranging from smartphones to supercomputers.

1. Smartphone AppMania continues
The explosion of application development on smartphone platforms like the iPhone and G1 continues, particularly in location-based services, social interaction and gaming. More computer science departments offer smartphone application development classes. There is more standardization of USB, earphone and other ports. U.S. ARPU is over $100/month.

2. Twitter is the platform
Despite renowned technical glitches, thousands more flock to messaging-leader Twitter and the fastest-growing user group of the microblogging notification system is non-human tweeters using the service as a data platform, example: Kickbee. Web 2.0 continues to bring back network computing, turning the web into the computer and human and object-based messaging becomes the new RSS.

3. Minis go mainstream
Mini PCs such as the Asus Eee PC, MSI Wind and Dell Inspiron continue to proliferate. Minis are fingertip candy; a travel machine for the on-the-go tech-savvy and too cheap to not be affordable for others at $200-$400.

4. Supercomputers achieve 8% human capacity
With IBM’s RoadRunner and Cray’s Jaguar running at just over 1 petaflop/s currently, the world’s fastest supercomputers could reach 1.5 petaflop/s in 2009 (unconfirmed results here), about 8% of the total processing capacity of the average human.

5. Chips: 32nm node rolls out amidst sales declines
Intel rolls out its 32nm node 1.9 billion transistor chip despite worldwide industry sales declines. Gartner forecasts a 4% decrease in chip sales in 2008 vs. 2007 and a 16% decrease in chip sales in 2009 vs. 2008. The biggest speedups continue to come from hardware, not software, and there could be additional breakthroughs in memory (flash, NRAM), magnetic disk storage, batteries and processor technology.

6. iWorld persists
The 200 millionth iProduct is sold before Apple’s CEO succession plan is in place.

7. WiMAX roll-out still stalled
WiMAX services could roll-out to 1-2 cities beyond Baltimore by year-end if Sprint and Clearwire’s operational and legal challenges are resolved. WiMAX would help to stratify connectivity offerings with a recession-attractive price point and bandwidth package (2-4 Mbps download, 1 Mbps upload speed; 6 month introductory price of $25/month, then $35/month).

8. More flexible media consumption models
More models for flexible on-demand pay/free video content viewing are launched for Tivo, Netflix, DVR, media PC and Internet consumers.

9. Video gaming grows
Video game titles, types and hours growth continues as escapism and low-cost entertainment options flourish.

10. Extended use of virtual worlds
Virtual world penetration and proliferation continues (Sony’s recent launch: PlayStation Home) at a slow and steady pace for both entertainment and serious use. The largest platform, Second Life, saw a 50% year-over-year increase in total hours and a 100% year-over-year increase in land ownership (much less exposure to virtual subprimes), and this rate of growth could easily continue in 2009. In the natural evolution of the Internet, virtual worlds continue expanding from the 3 Cs (communication, collaboration and commerce) to more advanced rapid prototyping, simulation and data visualization.


Other advances that could be around the corner:

• Speech-recognition version of Google translate
• More automated quantified self-measurement tools like the GoWearFit and FitBit
• Device convergence, one example: automated quantified self-measurement sensors built directly into existing mobile devices (G3?)
• In Brain-computer interfaces (BCIs), basic video gaming avatar movement functionality via non-invasive EEG-based helmet; not quite working yet
  

Still waiting, a few other (non-comprehensive) opportunities:

• Semantic web
• Natural language processing
• VLT (very long-term) laptop batteries
  
• Wireless power
• Ubiquitous free Wi-Fi
• Paper-thin reader for newspapers, eBooks and any printed content
• Cognition valet and other AI services

Mobile surveillance?

Are location-based services (LBS) quickly becoming the next FaceBook? Loopt would be one prominent example. As the number of Internet-enabled and GPS-enabled mobile phones proliferates with the spread of the iPhone and the two-year upgrade cycle for mobile devices, about 45% of mobile devices in the U.S. now have wireless broadband access. Local search and other mobile applications can finally be realized.

Location-based services, also called location-aware services, are about finding out what is nearby and who is nearby.

The what is fairly straightforward. This is more granular and possibly dynamic information about the places nearby; restaurant and store reviews, movie times, historical information for self-tours, etc. and the ability to take action, to make reservations, buy tickets, etc.

The who is related to people you know and people you don’t know. One social application is enabling your geographical location to be seen to friends in your network so they can easily find you. Another application is chat networks for people that are nearby, waiting somewhere for example, that would like to meet or just chat anonymously. There are also public-space interaction projects, games, art, etc. where people can use their cell phones to interact with a billboard or display, playing a video game against someone else in Times Square or making billboard art, either directly with call or text input or ambient algorithms following network participants as they pass through the area.

Age-tiering of technology
Twenty-somethings may be happy to permission their friend network to see where they are and senior-monitoring could be desirable but are age tiers 30-70 as interested in this functionality? Is the last modicum of privacy breached when your friends and family can see that you are at the gym, the dry cleaner, not at your office, etc. or is it too plebeian to care if everyone does it? Cell phones mean we can be reached everywhere, but do we want to be seen everywhere?