Synbio Reformulates the Traditional Scientific Method

Synthetic biology continues to be one of the most wide-spread trends reshaping the conduct of science.

Lauded as the potential ‘transistor of the 21st century’ given its transformative possibilities, synthetic biology is the design and construction of biological devices and systems. It is highly multi-disciplinary, linking biology, engineering, functional design, and computation.

One of the key application areas is metabolic engineering, working with cells to greatly expand their usual production of substances that can then be used for energy, agricultural, and pharmaceutical purposes.

Since the nature of synthetic biology is pro-actively creating de novo biological systems, organisms, and capacities (the opposite of the esprit of the passive characterization of phenomena for which the original scientific method was developed), synbio is reformulating the traditional scientific method.

While it is true that optimizing genetic and regulatory processes within cells can be partially construed under the scientific method, the overall scope of activity and methods are much broader.

Innovating de novo organisms and functionality requires a significantly different scientific methodology than that supported by the traditional scientific method. This includes computational modeling and simulation, engineering practices, feedback loops, automated bio-printing, and a re-conceptualization of science as an endeavor of characterizing and creating.

Artworld's Reaction to Citizen Art: not like Science and DIYscience

Considering the tradition of the highly-regarded place of science in society and the venerated scientific method, it is surprising that the ScienceWorld has deigned to notice Citizen Science and DIYscience efforts. Initially, the reaction of science may have generally been to dismiss citizen science, however, in many cases, perspectives shifted to wondering how to collaborate with citizen science efforts and how low-cost world-wide accessible Internet models could help to crowdsource study participants, data analysis, and other aspects of studies. The ecosystem became a continuum ranging from institutional science ('high science') to the individual n=1 quantified self experimenter ('citizen science as the venture capital arm (e.g.; starter, feeder, interest-surfacer) of science').(More)

Now the advent of new media has democratized the tools for art production. It is much easier for individuals to express themselves creatively in many different digital art venues and genres. Some of the tools that facilitate individual and collaborative creativity include Garage Band, SoundCloud, Pinterest, the Spore creature creator, blogs, Twitter, and virtual worlds. It is therefore timely to ask about the ArtWorld's (e.g.; insiders: artists, museums, critics) potential reaction to Citizen Art. As opposed the ScienceWorld's reaction to Citizen Science, the ArtWorld's reaction to Citizen Art could be much more complex. This is because art has been, and may always be something contentious. Key questions remain unsettled and even more pronounced with new media and digital art:

• what is art? 
• who can do art? 
• who can determine what is art? 
• what is the consecration process for art? 
• what is the societal and political role of art? what is the role of art as critique (of art, society, politics, etc.)? 
• is art autonomous from society? 
• what does the commercialization of art mean? 

Precisely because it is art, and not science, the acceptance of Citizen Art by the ArtWorld is much more nuanced than the tangible and quantitative nature of science, including Citizen Science, that makes results demonstrable. What is at stake is also more nebulous, although some new genres of digital art like SciArt, itself a mix of science and art, may be earlier to be acknowledged by the ArtWorld. (More)

Paradigm shifts in thinking

Biology has shifted from an art to a digital information science to an engineering problem.

Medicine has shifted from treatment to prevention and from normalization to enhancement.

Health has shifted from passive response to pro-activity.

Scientific method has shifted from hypothesis and experiment to simulation and empiricism.

Literacy has shifted from reading and writing to being able to express ideas in different forms of media such as software, 3d printing, virtual worlds and synthetic biology.

Revolutions in biology futures

Biology is continuing its progression from art to information science to engineering problem. As with many technology areas, advances in tools are driving a new era of science, and tools, science and paradigms are all evolving in biology.

DNA Sequencing
The technology for reading DNA, sequencing, is continuing to outpace Moore’s Law. Next-gen high-throughput sequencing leader Pacific Biosciences estimates their 15-minute $1000 genome solution will be on the market in 2013, more than surpassing the Archon X Prize requirements (100 people, 10 days, $10,000 per person).

DNA Synthesizing
The technology for writing DNA, synthesizing, is also extending its capability exponentially. The traditional methods involve laborious manual molecular biology tricks, oligonucleotide synthesis plus ligation, polymerase chain reaction (PCR) and polymerase assembly. These approaches have been supplanted by printing the code directly from a computer or ordering it from any of the 70 worldwide DNA synthesis foundries like Tech Dragon doing a billion dollars of business annually.

Personalized genomics and synthetic biology
The two biggest current revolutions are in personalized genomics and synthetic biology. Therapies are only in the early stages of development but personalized genetic information has the possibility of upstreaming healthcare to tailored medication and preventative interventions. Synthetic biology is using engineering to design and construct biological parts, devices and systems. The field has been developing a foundational library of standard and reliable open-source building block components; to date hundreds have been contributed to the Registry of Standard Biological Parts.

Scientific method yields to combinatorics
In any of the vast areas where biology is now an information science, empiricism and simulation are replacing the traditional scientific method. Instead of hypothesis and trial and error, nearly limitless combinations can be tested and studied for objective understanding of biological phenomena.

A more detailed look at Biology Futures is available here.